Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project
Author(s):
Claudia Santucci 1, Arianna Natale 1, Claudio Pelucchi 1, Rossella Bonzi 1, Nuno Lunet 2 3 4, Samantha Morais 2 3, Jesús Vioque 5 6, Sandra González-Palacios 5 6, Nuria Aragonés 5 7, Gemma Castaño-Vinyals 5 8 9 10, Reza Malekzadeh 11, Mohammadreza Pakseresht 11 12 13, Eva Negri 14, Paolo Boffetta 14 15, M Constanza Camargo 16, Maria Paula Curado 17, Zuo-Feng Zhang 18, Stefania Boccia 19 20, Carlo La Vecchia 21, Marta Rossi 1
Abstract
Purpose: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk.
Methods: Five case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls. Odds ratios (OR) of GC and the corresponding 95% confidence intervals (CI) for tertiles of vitamin D intake were computed using logistic regression models adjusted for relevant confounders, including energy intake. The pooled ORs were computed using random-effect models.
Results: The pooled OR of GC for the highest compared to the lowest tertile of vitamin D intake was 1.06 (95% CI 0.80-1.39), with a p for heterogeneity of 0.019. No significant association was found across strata of sex, age, socioeconomic status, smoking status, alcohol intake, and vegetable and fruit consumption.
Conclusions: Our pooled analysis indicates that there is no association between dietary vitamin D and the risk of GC.
Keywords: Dietary vitamin D; Epidemiology; Gastric cancer; Pooled analysis
DOI: 10.1007/s00394-025-03768-w
Published:
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